N°3 – Universiteit Maastricht (UM)

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Research within the Department of Toxicogenomics of Maastricht University is focused on the application of existing and emerging omics-technologies, evaluating cellular responses at the level of gene expression (transcriptomics), gene expression regulations (epigenetics and microRNA analysis), the protein level (proteomics) or the level of the metabolome (metabolomics). In doing so, different platforms and technologies are being applied and compared, including microarray technologies and next generation sequencing. A significant part of ongoing projects aims to optimise and integrate their application to human cellular models, for developing in vitro assays for toxicity prediction. 

Second line of research activities within the Department is focussing on the development of omics based biomarkers (e.g. protein-, metabolic- and gene expression profiles) to be applied in translational studies, specifically focusing on toxicological risk evaluation of dietary and environmental exposures and risk-benefit analysis. The nature and complexity of the data (in volume and variability) demands highly developed processes of automated handling and storage. Therefore, the department specifically aims to develop and implement relevant bioinformatics and biostatistical approaches, in order to retrieve the maximal amount of toxicological information generated through these omics-based studies.

 

  • Key staff involved in the project (For more detailed information see the  Who-is-Who-Book)

Jos Kleinjans is professor of Environmental Health Science at UM and head of the Department of Toxicogenomics (TGX). He has 25 years experience in toxicology and biomarker research, and contributed to over 175 scientific articles on toxicology and environmental health sciences mainly focused on genetic toxicology. Currently, Prof. Kleinjans is the scientific director of the Netherlands Toxicogenomics Centre and he coordinates major toxicogenomics-related projects funded by national public funding bodies and by international institutions, in particular EU FP6 Integrated Projects carcinoGENOMICS, NewGeneris and EU FP7 diXa.

 

Dr. T. de Kok is Associate professor at the Department of Toxicogenomics (TGX) of UM and has acknowledged expertise in the field of molecular toxicology, especially on genotoxicological processes in the gastrointestinal tract. He has published over 55 scientific papers. He will coordinate day-to-day activities in transcriptomics analyses.

 

 

 

 

 

 

Simone van Breda, Postdoc in geneexpression analysis and epigenetics.

 

 

 

Further information : www.maastrichtuniversity.nl/