N°15 – Universiteit Leiden (UL)

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Leiden/Amsterdam Center for Drug Research (LACDR; ~200 staff members) aims to be a leading academic center in the world in learning, teaching, and advancing innovative drug research, developing knowledge and expertise crucial for drug discovery, evaluation and (clinical) application. Understanding chemical safety issues is an important aspect. In this project UL will contribute to the development of fluorescent protein-based reporter cell models for toxicity prediction. We will apply these cell models in our high throughput live cell imaging infrastructure. Currently the division of Toxicology is an important partner of the Netherlands Toxicogenomics Center. Here we apply a systems toxicology approach to improve our understanding of chemical safety issues. As such we apply functional genomics strategy in combination with fast high throughput live cell imaging approaches to unravel mechanisms of cytotoxicity. This knowledge is integrated in improved in vitro models for prediction of unwanted effects of (novel) chemical  entities.


  • Key staff involved in the project (For more detailed information see Who-is-Who-Book)

Bob van de Water, Prof. Dr. He obtained his PhD (cum laude) at the Leiden/Amsterdam Center for Drug Research (LACDR) from Leiden University in 1995 and performed a postdoctoral training in the USA in the lab of Dr James Stevens. He joined the Division of Toxicology of the LACDR in 1997. In 2006, he was appointed as professor of drug safety sciences and head of the division of Toxicology. His research interest is on identifying molecular mechanisms of xenobiotic-induced cytotoxicity using a systems toxicology approach by integrating both gene expression profiling, phospho-proteomics and large scale RNAi-based functional genomics. He is heading the high throughput and high resolution imaging facility of the institute and applying this technology to better understand and predict cytotoxicity. In DETECTIVE he is projectleader for the organelle morphometry/function reporter cell lines and automated imaging analysis.



Other persons involved:

Mw. Dr. Sylvia Le Devedec, postdoc Cell biology and imaging
Dr. Bram Herpers, postdoc Hepatotoxicity/imaging
Mw. Dr. Marjo de Graauw, tenure track Nephrotoxicity/cell signaling
Mw. Ine Tijdens, technician Molecular biology


Further information : http://www.lacdr.nl/